In type 1 antithrombin deficiency, which combination of antigen and activity would you expect?

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Study for the Hemostasis Coagulation Test with detailed explanations and multiple choice questions to enhance your understanding. Prepare thoroughly for your examination!

Multiple Choice

In type 1 antithrombin deficiency, which combination of antigen and activity would you expect?

Explanation:
In type 1 antithrombin deficiency you have a quantitative shortage of the AT protein. Because there is less antithrombin present, measurements of the protein level (antigen) are reduced, and the functional tests show reduced ability to inhibit thrombin and factor Xa as well. So the combination you’d expect is decreased antigen and decreased activity. By contrast, a qualitative defect (type II) would have normal antigen but reduced activity.

In type 1 antithrombin deficiency you have a quantitative shortage of the AT protein. Because there is less antithrombin present, measurements of the protein level (antigen) are reduced, and the functional tests show reduced ability to inhibit thrombin and factor Xa as well. So the combination you’d expect is decreased antigen and decreased activity. By contrast, a qualitative defect (type II) would have normal antigen but reduced activity.

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