In thromboelastography, which sequence is reported to describe the progression of clot formation and dissolution?

In thromboelastography, which sequence is reported to describe the progression of clot formation and dissolution?

• A. Clot onset, aggregation, clot strength
• B. Clot onset, clot strength, fibrinolysis
• C. Aggregation, clot onset, clot strength
• D. Clot strength, fibrinolysis, clot onset

Answer: (B)

Thromboelastography tracks the timeline from the start of clotting through strengthening and finally breakdown. The initial phase is clot onset (time to first fibrin formation). Next, the clot strengthens as fibrin polymerizes and crosslinks, reflected in the rate and extent of clot formation and the development toward maximum strength. Lastly, fibrinolysis shows the clot being dissolved, reducing strength over time. So the sequence described is clot onset, clot strength, then fibrinolysis. Other sequences that place aggregation before onset, or strength before the clot has formed, or fibrinolysis before onset, don’t align with how the TEA trace evolves.

Thromboelastography tracks the timeline from the start of clotting through strengthening and finally breakdown. The initial phase is clot onset (time to first fibrin formation). Next, the clot strengthens as fibrin polymerizes and crosslinks, reflected in the rate and extent of clot formation and the development toward maximum strength. Lastly, fibrinolysis shows the clot being dissolved, reducing strength over time. So the sequence described is clot onset, clot strength, then fibrinolysis. Other sequences that place aggregation before onset, or strength before the clot has formed, or fibrinolysis before onset, don’t align with how the TEA trace evolves.