In DIC, which laboratory finding is most characteristic?

In DIC, which laboratory finding is most characteristic?

• A. Prolonged PT with normal D-dimer
• B. Prolonged aPTT with normal D-dimer
• C. Elevated D-dimer
• D. Normal coag tests

Answer: (C)

Disseminated intravascular coagulation (DIC) is a state of widespread clotting with consumption of platelets and coagulation factors, followed by increased fibrinolysis as the body tries to break down the clots. The most characteristic lab feature is a marked elevation in D-dimer, which is a degradation product of cross-linked fibrin. This reflects extensive fibrin formation and breakdown happening throughout the circulation. While prolonged PT and aPTT and low platelets are common in DIC, they are less specific than a high D-dimer. So, seeing an elevated D-dimer best signifies the active fibrin turnover that defines DIC.

Disseminated intravascular coagulation (DIC) is a state of widespread clotting with consumption of platelets and coagulation factors, followed by increased fibrinolysis as the body tries to break down the clots. The most characteristic lab feature is a marked elevation in D-dimer, which is a degradation product of cross-linked fibrin. This reflects extensive fibrin formation and breakdown happening throughout the circulation. While prolonged PT and aPTT and low platelets are common in DIC, they are less specific than a high D-dimer. So, seeing an elevated D-dimer best signifies the active fibrin turnover that defines DIC.